« Older Entries

4 reasons for you to invest in term life insurance

The concept of term life insurance has always been popular. It is said that investment in term life actually makes more monetary sense than investing in an endowment insurance cover. Some people are not aware of this form of insurance, but they must find out about it so that they are able to reap the benefits of this form of insurance. If you are interested in this form of insurance, you can easily access term life insurance quotes online and make your decision.

If you have been hearing about term life insurance for the first time, let us clarify this concept for you. A term insurance is for a fixed term that varies as per the terms and conditions of the cover. The term can be anything and you are covered throughout its duration. The only difference between this form of insurance and endowment insurance is that there is no return upon maturity in case of the former. But it still makes sense to buy this insurance cover because of the many benefits that are on offer.

More value for money
When you go through term life insurance quotes, you will find that this form of insurance is much cheaper than endowment insurance. For a much smaller premium amount, you get covered for a higher amount. When you buy term life insurance, you know that your beneficiaries stand to gain much more in the event of your unfortunate death. This alone is a great relief for anyone and it shouldn’t be any different for you.

Less complicated
Most of the endowment insurance policies are difficult to understand. There are so many calculations that you are invariably lost in the maze. On the other hand, term life insurance is simple to understand. You can instantly see that if you pay “x” amount, you are covered for “y” amount and that’s about it.

No emotional selling possible
Endowment policies come with a host of options including child plans and wealth plans. There is always a psychological bias embedded into these forms of cover. And this means you end up paying much more in the form of premium. A term life insurance cover is devoid of all this and there is no emotional selling possible. You know what your beneficiary gets and are able to the decision then and there.

Choice of riders
However, some term life policies also have riders that you can choose from. These riders may be associated with critical illness or injury or accidental death and so on. However, these riders are also easy to understand and you can make an instant decision.

It is clear to see why term life insurance is popular among insurance buyers. People feel that they stand to gain more from this form of insurance cover, both in the short and the long term. Find out more about this form of insurance and access some term life insurance quotes. You will find this cover easy to buy and then you are covered for as long as you want.

It is easy to buy term life insurance because of its simplicity. Go through term life insurance quotes and you can make an instant decision.

—

Tags:

What Are The Culinary Uses Of Chili Powder?

Chili powder is hot and is used all around the world to spice up food and stimulate taste buds; it is also used to give special color and aroma to cuisines. Chili or Chili pepper is native to Central America and is used in Mexican cuisines since centuries. Chili plant is perennial small shrub that grows up to a meter height, it bears white flowers and its fruits can be fleshy, mild, Mexican bell peppers or finger like green in color commonly grown all over India. Fruit is either plucked when green or is allowed to dry, it is either used fresh as green chili or is dried and grounded to make powder. When dried, green chili turns into red, however chili is found in many attractive colors like yellow, mustard and black.

Culinary Uses of Chili Powder

Red Chili powder or pepper can be used in any cuisine except sweets to enhance taste and increase heat. Chili in powdered form is used with curd, yoghurt, sprinkled over fried potato dishes etc.

Chili sauces are excellent support to enhance taste and heat of the food, take habanoras or Serrano chili, add two tablespoons of Lime juice and one tablespoon of Orange juice mince together and serve. It works as smacking taste enhancer.

Add Chili powder to soups to enhance its taste and nutritional value, one very tasty cuisine is barley and bean soup. Use Olive oil to cook and add garlic and Red Chili powder, stir to let them combine evenly and add barley, beans and water to make a delicious and nutritious soup.

Red chili powder can add extra spice and heat to tomato sauce. Add some Chili powder to minced tomatoes and make sauce for improved taste.

Chili paste will help a lot while cooking and it can be prepared quite easily. Take dried red chilies and break them into pieces, boil for 30 minutes with water to make a paste. This paste stays fresh for 10 days in a refrigerator and can be topped on crackers, fried potatoes, vegetables, gravies and as meat rub.

Chili infused oil are endlessly useful, it can be used for saut�©ing food, salad dressing, with vegetable marinades and meat. Cooking in Chili infused oil is easiest way to enhance taste of food.

Chili infused Vinegar is smacking substitute for simple Vinegar; it can be used for pickling, dressing, vegetable topper and with bread. Chili infused vinegar is good substitute for oils used in meat marinades and for making puddings and sauces.

—

Tags:

Science: Knockout of this epigenetic gene gives CAR-T cells the ability to continuously attack cance

Simply put, CAR-T is to transform the patient’s immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells.

In 2017, CAR-T therapy was first approved by the FDA for the treatment of blood cancers such as leukemia and lymphoma.

The successful application of CAR-T therapy has renewed hope for many desperate people, who are waiting for bone marrow matching. This also marks the arrival of the era of cell therapy.

Today, CAR-T has become one of the most important new developments in cancer immunotherapy, and many breakthroughs have been made in hematological tumors, but CAR-T therapy is usually limited by T cell failure.

However, those CAR-T cells lacking the DNA methyltransferase 3α (DNMT3A) gene usually have the ability to continuously attack cancer cells.

Recently, St. Researchers at Jude Children’s Research Hospital published a research paper entitled “The Deleting DNMT3A in CAR-T cells Enhancement Antitumor Activity Prevention” in the Science Translational Medicine.

Studies have shown that knockdown of DNA methyltransferase 3α (DNMT3A) gene in CAR-T cells can prevent T cell failure and enhance anti-tumor activity. These results suggest that DNMT3A can be used as a universal target to improve the therapeutic effect of CAR-T, providing a new roadmap for the development of more effective CAR-T cell therapy.

CAR-T cell therapy is revolutionizing the treatment of human cancers. In addition to significant results in some blood cancers, an increasing number of studies are beginning to use CAR-T cell therapy to penetrate solid tumors and chronic viruses.

Although clinical trials have demonstrated the therapeutic potential of CAR-T cell therapy, CAR-T cell therapy faces an important problem—CAR-T cell failure, which is affected by continuous antigenic stimulation in the tumor microenvironment. It becomes unresponsive, inhibits more and more receptors, and loses its effector function. However, the specific mechanism behind this is unknown.

Previously, the research team had been working on bone marrow transplantation and cell therapy.

They confirmed that epigenetic regulation is directly involved in T cell failure, which has a great impact on the clinical response to cell therapy.

The team also studied DNA methyltransferase 3α (DNMT3A) in a mouse model and in the setting of chronic viral infection.

These studies suggest that epigenetic modulation modulates long-term T cell memory.

In this study, the team found that CAR-T cell depletion was caused by epigenetic suppression of the pluripotent developmental potential of T cells.

After knockdown of DNA methyltransferase 3α (DNMT3A) gene in CAR-T cells, these CAR-T cells can usually maintain their proliferation and anti-tumor response ability after prolonged exposure to tumors.

The team further found that knockdown of DNMT3A resulted in enhanced CAR-T cell function combined with up-regulation of interleukin 10 (IL-10), and determined the genetic map of epigenetic silencing by genome-wide methylation analysis.

This figure analyzes the depletion of CAR-T cells at the molecular level, including many transcriptional regulators that limit the “stemness” of immune cells, including CD28, CCR7, TCF7, and LEF1.

Finally, the team also demonstrated that this epigenetic regulation is closely related to the clinical results of previous CAR-T cell therapy.

These data document the key role of epigenetic mechanisms in limiting the fate potential of human T cells and provide a roadmap for the use of this information to improve the efficacy of CAR-T cell therapy.

Regarding these findings, Giedre Krenciute, co-corresponding author of the paper, said that CAR-T treatment is tumor-specific and may be more effective and safe than conventional treatments such as chemotherapy or radiotherapy.

This study shows that knocking out the DNMT3A gene of CAR-T cells will indeed be more effective regardless of the tumor type or antigen targeted.

This highlights the central role of DNMT3A in controlling human CAR-T cell function, with the hope that this study will enter clinical translation as soon as possible.

Tags: